Chronic Diabetic Wounds and Their Treatment with Skin Substitutes
نویسندگان
چکیده
منابع مشابه
Case studies: treatment of chronic wounds with cultured skin substitutes.
This report of four patients (2 male, 2 female) presents preliminary results of treatment of chronic skin wounds with cultured skin substitutes prepared from allogeneic human skin cells and collagen substrates. The patients ranged in age from 64 to 73 years (mean: 67.25). The etiologies of their wounds were saphenous veinectomy, venous stasis, peripheral vascular disease, and venous stasis, wit...
متن کاملTreatment of Leg Chronic Wounds with Dermal Substitutes and Thin Skin Grafts
Tissue repair is a natural process occurring any time the skin is injured. Repair is achieved through different successive phases: inflammation, formation of granulation tissue, forma‐ tion of the extracellular matrix (ECM), and remodeling. ECM plays an important role in tis‐ sue regeneration representing the principal component of the dermal skin layer. The composition of ECM includes proteogl...
متن کاملTreatment of Chronic Wounds with Cultured Skin Substitutes: A Pilot Study
Chronic wounds in skin persist because the normal process of wound healing is obstructed. Failures occur in the inflammation and proliferation phases of wound healing that reduce formation of granulation tissue and prevent epithelial migration to close the wound, resulting mostly from vascular insufficiencies of multiple etiologies. Microbial contamination of chronic wounds also contributes imp...
متن کاملModeling the effects of treating diabetic wounds with engineered skin substitutes.
In this paper, a novel mathematical model of wound healing in both normal and diabetic cases is presented, focusing upon the effects of adding two currently available commercial engineered skin substitute therapies to the wound (Apligraf) and Dermagraft). Our work extends a previously developed model, which considers inflammatory and repair macrophage dynamics in normal and diabetic wound heali...
متن کاملFabrication, quality assurance, and assessment of cultured skin substitutes for treatment of skin wounds
Advances in treatment of skin wounds depend on demonstration of reduced morbidity or mortality either during or after hospitalization. Tissue engineering of skin grafts from cultured cells and biopolymers permits greater amounts of grafts from less donor tissue than conventional procedures. Autologous keratinocytes and fibroblasts isolated from epidermis and dermis of skin may be combined with ...
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ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10030655